Self-assembling DNA supramolecular structures containing two distinct conformational domains
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National Library of Canada , Ottawa
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
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Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers the possibility of enhancing the tunability and functionality of this class of materials. We report on the synergistic multicomponent self-assembly involving a peptide amphiphile (PA) and a 1,4-dibenzylidene-d-sorbitol (DBS) gelator to Cited by: In this context, we report on the direct conjugation of the protein A mimicking peptide Z33, a motif containing two α-helices, to linear hydrocarbons to create self-assembling IAs and demonstrate for the first time that the resultant supramolecular immunofibers (IFs) possess high binding affinity to human IgG1.
Similar to protein A, the chosen.
Details Self-assembling DNA supramolecular structures containing two distinct conformational domains FB2
The central goal of nanobiotechnology is to design and construct novel biomaterials of nanometer sizes. In this short review, we describe recent progress of several approaches for designing and creating artificial self-assembling protein complexes and primarily focus on the following biotechnological strategies for using artificial and fusion proteins as nanoscale building blocks: fusion Cited by: In supramolecular materials, molecules are assembled into molecular architectures with function .The assembly process is driven by noncovalent, relatively weak, and thus reversible interactions between the molecules .Self-assembly of molecules has been an active field of research, in part because the increasing understanding of the process has allowed to develop structures with Cited by: 4.
By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential.
X-ray analysis of two crystals diffracting to and angstroms resolution, which had slight variations in their unit-cell parameters, revealed two distinct conformations of the A-DNA helix. Life-inspired protein supramolecular assemblies have recently attracted considerable attention for the development of next-generation vaccines to fight against infectious diseases, as well as autoimmune diseases and cancer.
Protein self-assembly enables atomic scale precision over the final architecture, with a remarkable diversity of structures and functionalities. Organic materials naturally lend themselves to the crafting of structure and function using the strategies of self-assembly and supramolecular chemistry employed so effectively by biological systems.
This perspective illustrates progress over the past two decades on self-assembly in materials chemistry through research on systems where function is directly linked to noncovalent interactions. Inoligomer-sized “rodcoil” monomers, so-called because of their structure containing molecularly rigid and flexible domains, were reported to self-assemble into zero-dimensional supramolecular an architectural perspective, the mushroom-shaped aggregates of high collective molar mass, on the order of 10 5 daltons, are supramolecular polymer equivalents to dendrimers.
Supramolecular Chemistry. Deals with the chemistry and collective behavior of organized assembles of molecules. In this mesoscale regime, molecular building blocks are organized into longer range order and higher order structure via comparativlely weaker force such as H-bonding, dipoledipole interactions, Vander-waals forces and hydrophilic-hydrophobic interactions.
Here we report a theoretical investigation of two-component, self-assembling systems in order to rationalize chiral amplification in cooperative supramolecular copolymerizations. two different. One self-assembling polypeptide nanoparticle was composed of linear peptide monomers containing two coiled-coil oligomerization domains (pentameric and trimeric domains).
Antigen epitopes were added to the N and C terminals flanking these self-assembling domains, and displayed on the nanoparticle surface when fully assembled. Molecular conformational flexibility can play an important role in supramolecular self-assembly on surfaces, affecting not least chiral molecular assemblies.
To explicitly and systematically investigate the role of molecular conformational flexibility in surface self-assembly, we synthesized a three-bit conformational switch where each of three switching units on the molecules can assume. 2 Supramolecular self-assembly — concept and principles.
Lehn described supramolecular chemistry as the instruction set for the creation of a large complex assembly contained within its constituent components [1–3].Supramolecular self-assembly can be defined as the spontaneous formation of organized structures from building blocks with the aid of multiple.
Here again, it is the structure that predisposes the function--in the case of a DNA-based motor, the transformation of B-to Z-DNA via addition of a cobalt complex was used to cause rotation of 2. the last few decades as indicated by the large number of articles, reviews, and books The emergence of supramolecular chemistry has had a profound effect on how efficiently chemists prepare structures of different sizes and shapes with dimension in the range of 1 to nm using spontaneous secondary interactions such as hydrogen bonding.
PDF | Nature provides copious examples of self-assembling supramolecular nanofibers. Among them, amyloid structures have found amazing applications as | Find, read and cite all the research you.
Recently, the design of novel supramolecular chiral materials has received a great deal of attention due to rapid developments in the fields of supramolecular chemistry and molecular self-assembly. Supramolecular chirality has been widely introduced to polymers containing photoresponsive azobenzene groups.
On the one hand, supramolecular chiral structures of azobenzene-containing. This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology.
Many novel structures have been realized in the past decade, which are now being used to create molecular. DNA- and protein-based self-assembling hydrogels offer an opportunity to use some of biology's most functional building blocks.
Description Self-assembling DNA supramolecular structures containing two distinct conformational domains FB2
For example, collagen-based hydrogels have shown how chondrocytes preferentially reside on fibres and fibrillar hydrogels mimicking the ECM structure can be made from self-assembling cellulose. DNA is renowned for its double helix structure and the base pairing that enables the recognition and highly selective binding of complementary DNA strands.
These features, and the ability to create DNA strands with any desired sequence of bases, have led to the use of DNA rationally to design various nanostructures and even execute molecular computations.
Of the wide range of self-assembled. From Preorganization Toward Self-Organization and Programmed Systems: Design. Supramolecular chemistry has first relied on preorganization for the design of molecular receptors effecting molecular recognition, catalysis, and transport processes (1, 2).Supramolecular preorganization also has provided new ways and means to chemical synthesis (1, 7–9).
This study involved two self-assembling peptides, RADAI and RVDVI, of which RVDVI was a novel self-assembling peptide with different hydrophobic side chains designed from RADAI. DNA nanotechnology is the design and manufacture of artificial nucleic acid structures for technological uses.
In this field, nucleic acids are used as non-biological engineering materials for nanotechnology rather than as the carriers of genetic information in living chers in the field have created static structures such as two- and three-dimensional crystal lattices, nanotubes.
Supramolecular nanoarchitectonics based on self-assembling processes is not limited to the self-assembly of organic molecules.
As examples of precise crystalline assembly, Pileni have discussed sensitive mechanisms for supramolecular growth using 5 nm Au nanocrystals as building blocks in the self-assembling process.
79 M. Bifunctional 2-ureido-4[1H]-pyrimidinone (UPy) derivatives can form small cyclic oligomers as well as long supramolecular polymers in chloroform solutions using the quadruple hydrogen-bonding motif. Ring−chain equilibria of a set of supramolecular monomers containing methyl-substituted alkyl linkers between the hydrogen-bonding UPy moieties were investigated by 1H NMR spectroscopy and.
Supramolecular Chemistry: Structure and Dynamics at the Topological, Geometric, and Chemical Level. Supramolecular chemistry has been defined (1, 2) in various ways such as the chemistry of molecular assemblies and the intermolecular bond, chemistry beyond the molecule, and chemistry of the noncovalent of these definitions is useful as are others, but each has.
Telomeres are DNA−protein structures at the ends of eukaryotic chromosomes, the DNA of which comprise noncoding repeats of guanine-rich sequences.
Telomeric DNA plays a fundamental role in protecting the cell from recombination and degradation. Telomeric sequences can form quadruplex structures stabilized by guanine quartets. These structures can be constructed from one, two, or.
Hierarchical structures consisting of larger triangular clusters emerge upon further increasing X HA to (Fig. S21†). At an X HA ofDBA-OCOH produces a mixed phase of hierarchical clusters containing the n = 12 cluster as the major component (ca.
27%) together with other clusters of similar sizes (n = 10, 11, 13 Fig.
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The Double Helix. DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) are composed of two different classes of nitrogen-containing bases: the purines and most commonly occurring purines in DNA are adenine and guanine. Figure Purines The most commonly occurring pyrimidines in DNA are cytosine and thymine.
Figure Pyramidines. The basic interfacial characteristics of DNA–lipid recognitions have been studied. The complex structures of individual unbound DNA molecules and their binary and ternary complexes with zwitterionic lipids and divalent cations were followed by employing lipid monolayers at the air–liquid interfaces, as well as by performing various microscopic, spectroscopic, and thermodynamic .The α-helical barrel structure allows the bacteriophage to infect cells using the PhiX DNA pilot protein H in order to form a DNA translocating channel.
20 The protein H has been shown to exist of 10 α-helical structures, which form a Å long and 48 Å wide decameric coiled-coil structure. Because each monomer is kinked at residues.The study aims to present a detailed theoretical investigation of noncovalent intermolecular interactions between different π–π stacking nitrogen substituted phenothiazine derivatives by applying second-order Møller-Plesset perturbation (MP2), density functional (DFT) and semiempirical theories.
The conformational stability of these molecular systems is mainly given by the dispersion-type.
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